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All Articles Tagged As: protein folding
 | Max Planck scientists have identified a key player in protein folding. ...> Full Article |
 | Using the exceptionally bright and powerful X-ray beams of the Advanced Light Source, Berkeley Lab researchers have discovered a critical control element within chaperonin, the protein complex responsible for the correct folding of other proteins. The "misfolding" of proteins has been linked to many diseases, including Alzheimer's, Parkinson's and some forms of cancer. ...> Full Article |
 | Munich-based physicists are opening a new window on protein folding, using a technique that lets them grab the ends of a single protein molecule and pull, making continuous, direct measurements as it unfolds and refolds. Their latest study of the protein calmodulin reveals a complex network of intermediate states along the way to functionally correct folded forms. Better understanding of protein folding is essential because incorrectly folded proteins cause diseases such as Alzheimer's and Parkinson's. ...> Full Article |
 | Computational methods of modeling protein folding have existed for a couple of decades. But they required hundreds of thousands of CPU hours to compute the folding dynamics of 40 amino acids proteins. Now, McGill researchers have developed algorithms able to predict correctly in 10 minutes on a single laptop, a coarse-grained representation of the folding pathways of a protein with 60 amino acids. ...> Full Article |
Proteins normally recognize each other by their specific 3-D structure. If the key fits in the lock, a reaction can take place. However there are reactions at the onset of which the key does not really have a shape. Chemists at the Technische Universitaet Muenchen and the Max Planck Research Unit for Enzymology of Protein Folding (Halle/Saale) have now shown how this might work. Their results will appear in PNAS this week.
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 | Rice University researchers have come up with a computer program to accurately simulate protein folding dramatically faster than previous methods. It will allow scientists to peer deeper into the roots of diseases caused by proteins that fold incorrectly. ...> Full Article |
Physicists at UC Santa Barbara have created a microscopic device to assist biologists in making very fast molecular measurements that aid the understanding of protein folding. This development may help elucidate biological processes associated with diseases such as Alzheimer's and Parkinson's. Since proteins in the body perform different functions according to their shape, the folding process is considered a key area of study.
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 | A new technique to study protein dynamics in living cells has been created by a team of University of Illinois scientists, and evidence yielded from the new method indicates that an in vivo environment strongly modulates a protein's stability and folding rate. ...> Full Article |
In a new study in archaea (single-celled organisms without nuclei to enclose their genetic information), a consortium of researchers from Baylor College of Medicine and Stanford University in California discovered how the Group II chaperonins close and open folding chambers to initiate the folding event and to release the functional protein to the cell. A report of their work appears in the current issue of the journal Nature.
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Biophysicists the Technische Universitaet Muenchen have published results of single-molecule experiments bringing a higher-resolution tool to the study of protein folding. In PNAS they report taking hold of a single, zipper-like protein molecule with optical tweezers and mapping changes in its "energy landscape" during folding and unfolding, measuring thousands of transitions between states. This approach allows new insight into how proteins reach 3-D shapes that determine essential functions, or cause diseases when folding goes wrong.
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