All Articles Tagged As: misfolded proteins
 | Using the exceptionally bright and powerful X-ray beams of the Advanced Light Source, Berkeley Lab researchers have discovered a critical control element within chaperonin, the protein complex responsible for the correct folding of other proteins. The "misfolding" of proteins has been linked to many diseases, including Alzheimer's, Parkinson's and some forms of cancer. ...> Full Article |
Researchers have developed an algorithm to predict how and when proteins misfold, with potential implications for neurodegenerative diseases such as ALS and Alzheimer's. The team will present its findings at the 56th Annual Meeting of the Biophysical Society in San Diego, Calif.
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A protein's function depends on both the chains of molecules it is made of and the way those chains are folded. And while figuring out the former is relatively easy, the latter represents a huge challenge with serious implications because many diseases are the result of misfolded proteins. Now, a team of chemists at the University of Pennsylvania has devised a way to watch proteins fold in "real-time," which could lead to a better understanding of protein folding and misfolding in general.
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CSHL scientists have discovered hydrogen sulfide -- the flammable, toxic gas associated with the smell of rotten eggs in landfills -- helps regulate a signaling pathway implicated in biological malfunctions linked to Alzheimer's and Parkinson's diseases, among others.
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Scientists at Rochester Institute of Technology and Dowling College are matching proteins to the job they perform in the human body. Their research could lead to drugs that target proteins and switch on or off specific functions associated with various diseases. The three-year study is funded by a grant from the National Institutes of Health's National Institute of General Medical Sciences.
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Scientists at Northwestern University report a surprising discovery that offers a possible new route for the treatment of neurodegenerative diseases. In a study of the transparent roundworm C. elegans, they found that a genetic switch in master neurons inhibits the proper functioning of protective cell stress responses, leading to the accumulation of misfolded and damaged proteins.
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 | A large number of illnesses stem from misfolded proteins, molecules composed of amino acids. Researchers at the University of Zurich have now studied protein misfolding using a special spectroscopic technique. Misfolding, as they report in Nature, is more frequent if the sequence of the amino acids in the neighboring protein domains is very similar. ...> Full Article |
 | Using a sophisticated version of the stroboscopic photography Eadweard Muybridge used to prove in 1877 that a horse takes all four hooves off the ground when it gallops, Washington University scientist Michael Gross catches proteins in the act of folding, a process that can take less than thousandths of a second. ...> Full Article |
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