Proteomics News - September 2011 Archives
 | Online gamers have solved the structure of a retrovirus enzyme whose configuration had stumped scientists for over a decade. This is the first instance that researchers are aware of in which gamers solved a longstanding scientific problem. The discovery was achieved through Foldit, which allows players to collaborate and compete in predicting protein molecule structures. Foldit is an example of engaging the public in scientific discovery by using games to solve hard problems that can't be solved by either people or computers alone. ...> Full Article |
The crystal structure of the dynamin protein -- one of the molecular machines that makes cells work -- has been revealed, bringing insights into a class of molecules with a wide influence on health and disease.
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An ORNL invention able to quickly predict three-dimensional structure of protein could have huge implications for drug discovery and human health.
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 | In a joint study, scientists from the California and Florida campuses of the Scripps Research Institute have shown that changes in a protein's structure can change its signaling function and they have pinpointed the precise regions where those changes take place. ...> Full Article |
 | Study led by Zhen Y. Jiang, Ph.D. at Sanford-Burnham Medical Research Institute (Sanford-Burnham) identifies the protein -- called CDP138 -- that helps muscle and fat cells properly insert glucose transporters in their outer membranes. These results, appearing Sept. 7 in Cell Metabolism, provide a new understanding of glucose metabolism -- an important finding considering that impaired insulin action and glucose metabolism contribute to the development of type 2 diabetes. ...> Full Article |
A molecule which can stop the formation of long protein strands, known as amyloid fibrils, that cause joint pain in kidney dialysis patients has been identified by researchers at the University of Leeds.
The discovery could lead to new methods to identify drugs to prevent, treat or halt the progression of other conditions in which amyloid fibrils play a part, including Alzheimer's, Parkinson's and Type II diabetes.
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