Proteomics Research and News
In order to interact with the environment, bacteria secrete a whole arsenal of proteins. Researchers have now found how one of the transportation systems used for this purpose ? the type VI secretion system ? works for the single-celled organism Agrobacterium tumefaciens. They have identified the relevant transport proteins and their energy suppliers. With colleagues at the Academia Sinica in Taiwan, RUB biologist Prof. Dr. Franz Narberhaus describes the findings in the Journal of Biological Chemistry.
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 | Protein design is technique that is increasingly valuable to a variety of fields, from biochemistry to therapeutics to materials engineering. University of Pennsylvania chemists have taken this kind of design a step further; Using computational methods, they have created the first custom-designed protein crystal. ...> Full Article |
 | An international team of researchers has reported a new understanding of a little-known process that happens in virtually every cell of our bodies. ...> Full Article |
Rancorous budget debates between the Administration and Congress obscure the fact that the nation's leadership in science and innovation is tenuous at best if spending for research is cut drastically.
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A new method to reveal the structure of proteins could help researchers understand biological molecules -- both those involved in causing disease and those performing critical functions in healthy cells. For roughly a decade, a technique called solid state nuclear magnetic resonance spectroscopy has allowed researchers to detect the arrangements of atoms in proteins that defy study by traditional laboratory tools such as X-ray crystallography.
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 | A novel type of sensor, based on nanometer-scale pores in a semiconductor membrane, is a step closer to practical use in applications such as analyzing protein contents of a single cell. As reported in Nature Nanotechnology, a collaboration between researchers pioneering solid-state nanopore sensor technology at the Technische Universität München and biochemists at Goethe University Frankfurt has advanced this effort past a sticking point: Enhancing the sensor's selectivity while maintaining its sensitivity to single molecules. ...> Full Article |
 | Max Planck scientists have identified a key player in protein folding. ...> Full Article |
 | Using a unique facility in the US, researchers at the University of Gothenburg have found a more effective way of imaging proteins. The next step is to film how proteins work -- at molecular level. ...> Full Article |
A new semi-automated tool called pathwalking makes it possible to generate a "first draft" model of a protein fold taken from near-atomic resolution images of between three and six angstroms, said researchers at the National Center for Macromolecular Imaging in the department of biochemistry at Baylor College of Medicine.
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A new approach to disentangling the complexities of biological networks, such as the way in which proteins interact in our body's cells has been developed by researchers in China. The team's algorithm could allow biologists and biomedical researchers to unravel new clues about how cells work and what goes awry with such networks in various diseases, such as Alzheimer's disease and cancer.
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Mayo Clinic researchers have gained insights into the function of a member of a family of specialized proteins called histone chaperones.
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 | Using the exceptionally bright and powerful X-ray beams of the Advanced Light Source, Berkeley Lab researchers have discovered a critical control element within chaperonin, the protein complex responsible for the correct folding of other proteins. The "misfolding" of proteins has been linked to many diseases, including Alzheimer's, Parkinson's and some forms of cancer. ...> Full Article |
Researchers have developed an algorithm to predict how and when proteins misfold, with potential implications for neurodegenerative diseases such as ALS and Alzheimer's. The team will present its findings at the 56th Annual Meeting of the Biophysical Society in San Diego, Calif.
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Scientists find that the unfolded end of a protein can kill E. coli-like bacteria selectively. The results, which will be presented at the 56th Annual Meeting of the Biophysical Society, may one day help scientists find new, more targeted ways to kill antibiotic-resistant microbes.
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Proteins, the building block for all living organisms, are the ultimate transformers -- able to splice and switch roles and functions within the human body. But when these changes go wrong, diseases such as cancers and arthritis may result, says University of British Columbia researcher Chris Overall.
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